I think one of the most important part in playing humans is optimizing the blocks, making sure you get a lot of opponents down and thus suffering less heat yourself. For my team, I'm at 11 CAS in three games (after having played Nurgle, Woodies and Necros), and I've only suffered 5 in return. With one or two players more than the opponent on the field, humans are nigh unstoppable. (The above is especially true early on in the leagues, as people normally only have 11 players in their teams.)
Of course, I've also geared almost all my skills in that direction, with 2x Guard, MB, and Piling On already on the team. I'm now looking at getting, for instance, Tackle on my MB player and MB + Piling On for the unskilled Blitzer.
Meanwhile, I strive to give the linemen skills that makes them better at taking heat (wrestle / fend) or being supportive (block / guard + 1x Kick).
Now I only have to figure out what to do with my +AG thrower

My current roster:
http://stridshammaren.se/bubble/handler ... detailed=0